The best replacement for v6 is v8.

The best alternatives to v6 are rated as following:
★★★★★  v8
★★★★★  v4
★★★★  4 cylinder
★★★  inline 6
★★  v8 mustang
★★  i4
★★  v8 engine
★★  v8 camaro
★  i6
★  v8 truck
★  v8 4runner
★  straight 6
★  v8 challenger
★  v8 jeep grand cherokee
★  v8 gas mileage
★  gt
  6 cylinder
  gt mustang
  camaro v6
  v8 silverado
  v8 range rover
  i4 accord
  7506
  v4 engine
  v8 durango
  mustang v6
  v8 grand cherokee
  v4 turbo
  4 cylinder engine
  i6 engines
  flat 6
  inline
  v8 sound
  6 inline
  4 cylinder engines
  turbo 4
  ecoboost
  4cyl
  straight six
  v8 charger
  v8 which is better
  inline 4
  v8 engines
  turbo
  v8 f1
  straight 6 engine
  vtec
  mdr 7506
  l4
  mustang gt

Your alternative for v6 is not listed? Suggest!
Speaking about v6, one probably shouldn't forget about v8 sound.

Other search terms related to v6 and their ratings are:
★★★★★ v8 sound
4 cylinder
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Google Trends

Scale is based on the average worldwide traffic of v6 in all years. Click on graph for more.
v6
v8
v4