The best replacement for u2 is coldplay.

The best alternatives to u2 are rated as following:
★★★★★  coldplay
★★  radiohead
★★  sr-71
★★  rolling stones
★★  bon jovi
★★  rem
★  metallica
★  global hawk
★  t6
★  green day
★  s2
★  sport2
★  pink floyd
★  muse
★  lmc
  daft punk
  negativland
  bono
  blackbird
  xml t6
  g2000
  sr71
  dire straits
  johnny cash
  u3
  busta
  depeche mode
  lyrics born

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Speaking about u2, one probably shouldn't forget about or without you.

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Google Trends

Scale is based on the average worldwide traffic of u2 in all years. Click on graph for more.
u2
coldplay
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