The best replacement for tweaker is rebel.

The best alternatives to tweaker are rated as following:
★★★★★  rebel
★★★★  rebel 20
★★★  night train
★★★  tubemeister
★★★  blues jr
★★  5 hour energy
★★  renegade
★★  junkie
★★  tiny terror
★★  ac15
★  class 5
★  rebel 30
★  transatlantic
★  crackhead
★  dt 25
★  classic 30
★  vox night train
  blackstar 20
  blackstar ht
  vox ac15
  blackstar ht5
  ac15c1
  peavey classic 30

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Google Trends

Scale is based on the average worldwide traffic of tweaker in all years. Click on graph for more.
tweaker
rebel
rebel 20