The best replacement for tu is usted.

The best alternatives to tu are rated as following:
★★★★★  usted
★★★★  vous
★★★★  su
★★★  ti
★★  tú
★★  toi
★  vos
★  tu
★  nadie
★  te
★  ud
★  tuyo
  osu
  toi french
  ut
  yo
  su spanish
  usteds
  ustedes
  ek mai
  vous french
  para ti
  tus

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Google Trends

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tu
usted
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