The best replacement for southern illinois is northern iowa.

The best alternatives to southern illinois are rated as following:
★★★★★  northern iowa
★★★  northern illinois
★★  missouri state
★★  holy cross
★  wichita state
★  creighton
★  evansville
★  illinois state
★  university of illinois
★  indiana state
  west virginia
  eastern illinois

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Google Trends

Scale is based on the average worldwide traffic of southern illinois in all years. Click on graph for more.
southern illinois
northern iowa
northern illinois