The best replacement for significant is substantial.

The best alternatives to significant are rated as following:
★★★★★  substantial
★★★★  significance
★★★★  important
★★★  insignificant
★★  meaningful
★★  statistically significant
★★  material
★★  non significant
★★  not significant
★★  clinically significant
★  significantly
★  successful
★  significant
★  considerable
★  signifier
  practically significant
  significative
  sf beauty

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