The best replacement for setter is pointer.

The best alternatives to setter are rated as following:
★★★★★  pointer
★★★★  golden retriever
★★  english setter
★★  irish setter
★★  english pointer
★★  price taker
★★  springer spaniel
★  brittany
★  stew
★  constructor injection
★  medicus
★  constructor injection spring
★  getter
★  red wing
  german shorthair
  gordon setter
  non setter
  brittany spaniel
  danner boots

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Speaking about setter, one probably shouldn't forget about getter.

Other search terms related to setter and their ratings are:
★★★★★ getter
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Google Trends

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setter
pointer
golden retriever