The best replacement for septra is bactrim.

The best alternatives to septra are rated as following:
★★★★★  bactrim
★★★  septra ds
★★  cipro
★  macrobid
★  suprax
★  nitrofurantoin
★  minocycline
  keflex
  sulfatrim

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No companions for septra have been suggested so far.
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