The best replacement for sam-e is 5-htp.

The best alternatives to sam-e are rated as following:
★★★★★  5-htp
★★★★★  st john's wort
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★★  methionine
★★  st johns wort
★  st. john\u0027s wort
★  rhodiola
★  st. john's wort
★  st. johns wart
★  htp-5
★  milk thistle
  5htp
  glucosamine chondroitin
  st john wort

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Speaking about sam-e, one probably shouldn't forget about st. john's wort.

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★★★ 5 htp
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★ st johns wort
5-htp
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