The best replacement for saffire 6 is scarlett 2i2.

The best alternatives to saffire 6 are rated as following:
★★★★★  scarlett 2i2
★★★★  scarlett 2i4
★★★★  scarlett 8i6
★★★★  saffire pro 14
★★★  fast track pro
★  pro 14
★  pro 24
  2i4

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saffire 6
scarlett 2i2
scarlett 2i4