The best replacement for s80 is s60.

The best alternatives to s80 are rated as following:
★★★★★  s60
★★★  audi a6
★★★  a6
★★  y80
★★  s4c
★★  bmw 5 series
★  bmw 5-series
★  md80
★  soloist
★  s40
★  sd550
★  9-5
★  a620
  zipp 808
  volvo s60
  hyundai genesis

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audi a6