The best replacement for rx350 is mdx.

The best alternatives to rx350 are rated as following:
★★★★★  mdx
★★★  rx450h
★★★  ml350
★★★  q5
★★  x5
★★  fx35
★★  highlander
★★  x3
★★  acura mdx
★  bmw x3
★  rx400h
★  rdx
★  venza
★  rx330
★  mkx
★  rx350 f sport
★  glk
★  qx60
★  audi q5
  2013 rx350
  srx
  acura rdx
  2009 acura mdx
  volvo xc60
  bmw x5
  xc60
  toyota highlander
  mercedes ml350
  ex35
  infiniti fx35
  2011 rx350
  glk350
  rx450
  2010 rx350
  volvo xc90

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Google Trends

Scale is based on the average worldwide traffic of rx350 in all years. Click on graph for more.
rx350
mdx
rx450h