The best replacement for rx 350 is acura mdx.

The best alternatives to rx 350 are rated as following:
★★★★★  acura mdx
★★★★  bmw x5
★★★  mdx
★★  audi q5
★★  q5
★★  x5
★★  bmw x3
★★  x3
★  toyota highlander
★  rx 400h
★  450h
★  murano
★  es 350
★  acura rdx
★  xc60
★  cadillac srx
★  mercedes ml
★  highlander
  volvo xc90
  rx 330
  volvo xc60
  2012 honda crv
  ml 350
  buick enclave
  infiniti fx35
  gmc terrain
  rx 450h
  lincoln mkx
  mercedes ml 350
  rdx
  nissan murano
  rx 450
  lexus rx 450
  glk350
  audi q7
  2011 lexus rx 350
  mercedes ml350
  srx

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Google Trends

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rx 350
acura mdx
bmw x5