The best replacement for rune is granite.

The best alternatives to rune are rated as following:
★★★★★  granite
★★★★★  dragon hatchet
★★★★  spitfire
★★★★  dragon pickaxe
★★★  dragon axe
★★  volumio
★★  granite armor
★  chilcotin
★  serum dragon age
  enchant
  granite better
  proselyte

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Google Trends

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rune
granite
dragon hatchet