The best replacement for ruger sr22 is walther p22.

The best alternatives to ruger sr22 are rated as following:
★★★★★  walther p22
★★★  sig mosquito
★★  mp22
★★  m&p 22
★★  p22
★  beretta neos
★  lcr 22
★  issc m22
★  s&w m&p 22
★  s&w mp15 22
★  browning buckmark
★  bersa thunder 22
  sig 522
  smith & wesson m p22
  m&p 22 pistol
  bersa 22
  s&w 22
  m&p 22 pistols
  taurus pt22
  mossberg 715t
  s&w 22a
  s&w m&p22
  walther

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ruger sr22
walther p22
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