The best replacement for rifaximin is lactulose.

The best alternatives to rifaximin are rated as following:
★★★★★  lactulose
★★★  neomycin
★  metronidazole
★  flagyl
★  xifaxan
  rifampin

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No companions for rifaximin have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of rifaximin in all years. Click on graph for more.
rifaximin
lactulose
neomycin