The best replacement for rewire is vst.

The best alternatives to rewire are rated as following:
★★★★★  vst
★★★★  re-wire
★★  soundflower
★  melodyne bridge

Your alternative for rewire is not listed? Suggest!
Speaking about rewire, one probably shouldn't forget about ableton.

Other search terms related to rewire and their ratings are:
★★★★★ ableton
★★★★ cubase
★★★ logic and reason
You have in mind a companion for rewire and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of rewire in all years. Click on graph for more.
rewire
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