The best replacement for refrigerant is freon.

The best alternatives to refrigerant are rated as following:
★★★★★  freon
★★★★★  r22
★★★★  r410a refrigerant
★★★  r 410a
★★★  r410a
★★★  antifreeze
★★  chilled water
★★  410a
★  puron
★  r12
★  r134a
★  r-22
  r-22 refrigerant
  coolant
  r22 refrigerant

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refrigerant
freon
r22