The best replacement for r-22 is r-410a.

The best alternatives to r-22 are rated as following:
★★★★★  r-410a
★★★  puron
★★★  410a
★★★  r-410
★★  r-134a
★  r-12
★  r-410a freon
★  r410a
  410a refrigerant
  410
  4-410a
  r-407c

Your alternative for r-22 is not listed? Suggest!
Speaking about r-22, one probably shouldn't forget about r-22a.

Other search terms related to r-22 and their ratings are:
★★★★★ r-22a
★ es 22a
★ r-12
You have in mind a companion for r-22 and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of r-22 in all years. Click on graph for more.
r-22
r-410a
puron