The best replacement for quadro 4000 is k4000.

The best alternatives to quadro 4000 are rated as following:
★★★★★  k4000
★★★★  gtx 680
★★★★  k2000
★★  fx 4800
★★  k5000
★  firepro v5900
  k600
  v7900
  quadro fx4800

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quadro 4000
k4000
gtx 680