The best replacement for pyridium is azo.

The best alternatives to pyridium are rated as following:
★★★★★  azo
★★★★  uristat
★★★  uribel
★★★  urelle
★★  oxybutynin
★★  cystex
★  ditropan
★  urogesic blue
★  urispas
★  uricalm
★  phenazopyridine
★  vesicare
★  azo standard
  pyridium plus

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Speaking about pyridium, one probably shouldn't forget about azo.

Other search terms related to pyridium and their ratings are:
★★★★★ azo
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