The best replacement for prototype 2 is infamous 2.

The best alternatives to prototype 2 are rated as following:
★★★★★  infamous 2
★★★★  saints row 4
★★★  infamous second son
★★  max payne 3
★  prototype
★  mass effect 3
  starhawk
  prototype 1
  marucci

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prototype 2
infamous 2
saints row 4