The best replacement for prempro is premarin.

The best alternatives to prempro are rated as following:
★★★★★  premarin
★★★★  activella
★★★  premphase
★★★  estradiol
★★★  bioidentical hormones
★★  femhrt
★★  angeliq
★  vivelle dot
★  combipatch
★  estrace
★  jinteli
★  estratest
★  estroven
  mimvey
  prempro
  bio identical hormones
  climara
  provera

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No companions for prempro have been suggested so far.
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Google Trends

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prempro
premarin
activella