The best replacement for panera is starbucks.

The best alternatives to panera are rated as following:
★★★★★  starbucks
★★★★★  chipotle
★★★★  corner bakery
★★  cosi
★★  einstein bagels
★★  au bon pain
★★  atlanta bread
★  qdoba
★  atlanta bread company
★  wildflower
★  boudin
★  st.louis bread co
★  bread co
★  paradise bakery
★  potbelly
  st louis bread company
  chick fil a
  bruegger's
  mcalister's
  paradise
  chipotle healthier

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Google Trends

Scale is based on the average worldwide traffic of panera in all years. Click on graph for more.
panera
starbucks
chipotle