The best replacement for paint tool sai is photoshop.

The best alternatives to paint tool sai are rated as following:
★★★★★  photoshop
★★★★  gimp
★★★  manga studio
★★  clip studio
★★  opencanvas
★★  manga studio 5
★  corel painter
★  paint.net
★  krita
★  photoshop cs6
★  sketchbook pro
★  artrage
★  open canvas
★  painter
  clip studio paint

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Google Trends

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paint tool sai
photoshop
gimp