The best replacement for osticket is otrs.

The best alternatives to osticket are rated as following:
★★★★★  otrs
★★★★★  spiceworks
★★★★★  zendesk
★★★★  hesk
★★★★  trellis
★★★★  e ticket
★★★  freshdesk
★★★  kayako
★  bugzilla
★  request tracker
★  glpi
  eticket

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Google Trends

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osticket
otrs
spiceworks