The best replacement for orencia is humira.

The best alternatives to orencia are rated as following:
★★★★★  humira
★★★★★  enbrel
★★★★★  remicade
★★★★  rituxan
★★★  actemra
★  simponi
★  cimzia
  abatacept
  xeljanz

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Google Trends

Scale is based on the average worldwide traffic of orencia in all years. Click on graph for more.
orencia
humira
enbrel