The best replacement for operation is surgery.

The best alternatives to operation are rated as following:
★★★★★  surgery
★★★★  operations
★★  process
★★  project
★★  procedure
★  method
★  cooperation
★  normal delivery
  production management
  service operation
  normal birth
  production
  surgical procedure
  minor operation
  joint venture
  physical control
  main effort
  discriminative stimulus
  administration
  old operation
  goods production
  manufacturing operation

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Google Trends

Scale is based on the average worldwide traffic of operation in all years. Click on graph for more.
operation
surgery
operations