The best replacement for ols is gls.

The best alternatives to ols are rated as following:
★★★★★  gls
★★★★★  mle
★★★  logistic regression
★★★  2sls
★★★  probit
★★  glm
★  gwr
★  poisson
★  fixed effects
  logit
  least squares
  maximum likelihood
  gmm
  wls

Your alternative for ols is not listed? Suggest!
Speaking about ols, one probably shouldn't forget about robust standard errors.

Other search terms related to ols and their ratings are:
★★★★★ robust standard errors
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