The best replacement for observational study is experiment.

The best alternatives to observational study are rated as following:
★★★★★  experiment
★★★★★  designed experiment
★★★★  experimental study
★★  randomized experiment
★★  survey
★★  clinical trial
★  rct
★  an experiment
★  controlled experiment
★  controlled study
★  sample survey
★  experiment statistics
★  experimental
  natural experiment
  interventional study
  clinical study
  non-interventional study
  registry

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Google Trends

Scale is based on the average worldwide traffic of observational study in all years. Click on graph for more.
observational study
experiment
designed experiment