The best replacement for nopal cactus is prickly pear.

The best alternatives to nopal cactus are rated as following:
★★★★★  prickly pear

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Speaking about nopal cactus, one probably shouldn't forget about hoodia.

Other search terms related to nopal cactus and their ratings are:
★★★★★ hoodia
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nopal cactus
prickly pear