The best replacement for microsoft excel is access.

The best alternatives to microsoft excel are rated as following:
★★★★★  access
★★★  microsoft access
★★  lotus 123
★  open office calc
★  quattro pro
★  microsoft word
★  openoffice calc
★  microsoft works spreadsheet
★  apple numbers
★  google spreadsheet
★  spreadsheet
★  calc
  microsoft project
  corel quattro pro
  microsoft works
  mac numbers

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Speaking about microsoft excel, one probably shouldn't forget about data analysis.

Other search terms related to microsoft excel and their ratings are:
★★★★★ data analysis
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