The best replacement for mfc is .net.

The best alternatives to mfc are rated as following:
★★★★★  .net
★★★  win32
★★★  atl
★★  qt
★★  wpf
★  clr
★  mfp
★  dcp
★  winforms
★  wtl
★  windows forms
★  c#
★  api
  wxwidgets
  stl
  win32 api
  vcl
  winapi
  .net framework
  version info

Your alternative for mfc is not listed? Suggest!
Speaking about mfc, one probably shouldn't forget about opengl.

Other search terms related to mfc and their ratings are:
★★★★★ opengl
★★★★ visual studio express
★★★★ visual c++
★★★ c++
★★ visual studio 2010
★ visual c++ express 2010
★ visual c++ 6
★ visual c++ express
directx
vc++
You have in mind a companion for mfc and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of mfc in all years. Click on graph for more.
mfc
.net
win32