The best replacement for mercedes c300 is audi a4.

The best alternatives to mercedes c300 are rated as following:
★★★★★  audi a4
★★★★  bmw 328i
★★  bmw 3 series
★★  lexus is 250
★★  bmw 528i
★★  bmw 328
★★  infiniti g37
★  cadillac ats
★  328i
★  bmw 335i
★  lexus is
★  lexus is250
  lexus es 350
  lexus es350
  bmw 325i

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mercedes c300
audi a4
bmw 328i