The best replacement for mass effect 3 is skyrim.

The best alternatives to mass effect 3 are rated as following:
★★★★★  skyrim
★★★★  dead space 3
★★★  gears of war 3
★★★  deus ex human revolution
★★  borderlands 2
★★  halo 4
★★  bioshock infinite
★★  witcher 2
★  fallout new vegas
★  mass effect 2
★  max payne 3
★  dragon age 2
★  warframe
  prototype 2

Your alternative for mass effect 3 is not listed? Suggest!
Speaking about mass effect 3, one probably shouldn't forget about origin.

Other search terms related to mass effect 3 and their ratings are:
★★★★★ origin
★★★ tali
★★★ all dlc
You have in mind a companion for mass effect 3 and it is not yet here? Propose!



Google Trends

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mass effect 3
skyrim
dead space 3