The best replacement for malignant is benign.

The best alternatives to malignant are rated as following:
★★★★★  benign
★★  metastatic
★★  benign tumor
★★  benign hypertension
★★  benign tumors
★★  accelerated hypertension
★  benign melanoma
★  benign cancer
★  cancerous
★  nonmalignant
★  benign cyst
★  essential hypertension
★  non malignant
★  benign brain tumors
★  benign thyroid nodules
★  benign breast tumor
★  benign moles
★  benign skin cancer
★  banine
  benign brain tumor
  metastasis
  benign bone tumor
  benign breast cancer
  benine
  benign mole
  benin
  begnin
  benign breast lumps
  benign definition
  benign lesions
  benign breast tumors
  serotonin syndrome
  begin

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No companions for malignant have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of malignant in all years. Click on graph for more.
malignant
benign
metastatic