The best replacement for lexus rx is acura mdx.

The best alternatives to lexus rx are rated as following:
★★★★★  acura mdx
★★★  infiniti fx
★★★  audi q5
★★  bmw x5
★★  acura rdx
★  mercedes ml
★  volvo xc60
★  bmw x3
★  cadillac srx
★  nissan murano
★  toyota highlander
★  lincoln mkx
★  mdx
  q5
  mercedes glk
  audi q7
  touareg
  porsche cayenne
  venza
  mercedes m
  mercedes m class
  hyundai veracruz
  2010 lexus rx

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lexus rx
acura mdx
infiniti fx