The best replacement for lexus es350 is toyota avalon.

The best alternatives to lexus es350 are rated as following:
★★★★★  toyota avalon
★★★★  acura tl
★★★  infiniti g37
★★★  avalon
★  buick lacrosse
★  mercedes e350
★  mercedes c300
  hyundai genesis
  es330

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lexus es350
toyota avalon
acura tl