The best replacement for karela is bitter gourd.

The best alternatives to karela are rated as following:
★★★★★  bitter gourd
★★★  bitter melon

Your alternative for karela is not listed? Suggest!
Speaking about karela, one probably shouldn't forget about keema.

Other search terms related to karela and their ratings are:
★★★★★ keema
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karela
bitter gourd
bitter melon