The best replacement for jefe is lider.

The best alternatives to jefe are rated as following:
★★★★★  lider
★★★★  stomper
★★★★  remix
★★★★  jefa
★★  patron
★  gerente
★  lider video
★  empleado
★  hefe
  habitat
  jefe grande
  rajan

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Google Trends

Scale is based on the average worldwide traffic of jefe in all years. Click on graph for more.
jefe
lider
stomper