The best replacement for itself is its self.

The best alternatives to itself are rated as following:
★★★★★  its self
★★★★  themselves
★★★  themself
★★★  it self
★★  it\u0027s self
★★  in itself
★  on its own
★  chloride by itself
★  himself
★  class for itself
★  itself
★  in and of itself
  by itself
  flashpoint
  means to an end

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itself
its self
themselves