The best replacement for isotretinoin is accutane.

The best alternatives to isotretinoin are rated as following:
★★★★★  accutane
★★★★  tretinoin
★  roaccutane
★  tetracycline
  adapalene
  claravis
  antibiotics
  13 cis retinoic acid

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No companions for isotretinoin have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of isotretinoin in all years. Click on graph for more.
isotretinoin
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