The best replacement for isoflurane is sevoflurane.

The best alternatives to isoflurane are rated as following:
★★★★★  sevoflurane
★★★  desflurane
★★  ketamine
★★  halothane
★★  propofol
★  enflurane

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No companions for isoflurane have been suggested so far.
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Google Trends

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isoflurane
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desflurane