The best replacement for infect is hexproof.

The best alternatives to infect are rated as following:
★★★★★  hexproof
★★★★★  planeswalker
★★★★  infest
★★★★  indestructible
★★★  regenerate
★★★  undying
★★★  fog bank
★★  regenerate mtg
★★  shroud
★★  wither
★  first strike
★  totem armor
★  jund
  boros reckoner

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infect
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