The best replacement for indifference is hate.

The best alternatives to indifference are rated as following:
★★★★★  hate
★★★★★  apathy
★★  ambition amalur
★★  ambivalence
★  anger
★  detachment
★  indifferent
★  disinterest
★  stolen base
★  compassion
★  ignorance
  freedom of excellence
  tolerance

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Google Trends

Scale is based on the average worldwide traffic of indifference in all years. Click on graph for more.
indifference
hate
apathy