The best replacement for hypertonic saline is mannitol.

The best alternatives to hypertonic saline are rated as following:
★★★★★  mannitol
★★★★  normal saline
★★  isotonic saline
★  polidocanol
★  mucomyst
  mannitol intracranial hypertension
  isotonic

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Speaking about hypertonic saline, one probably shouldn't forget about bronchiolitis.

Other search terms related to hypertonic saline and their ratings are:
★★★★★ bronchiolitis
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