The best replacement for harm reduction is abstinence.

The best alternatives to harm reduction are rated as following:
★★★★★  abstinence
★★★  zero tolerance
★★  disease model
★  harm minimisation
★  use reduction
★  aa
★  total abstinence
★  harm induction
  risk reduction
  12 step
  war on drugs

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No companions for harm reduction have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of harm reduction in all years. Click on graph for more.
harm reduction
abstinence
zero tolerance