The best replacement for glock 21 is 1911.

The best alternatives to glock 21 are rated as following:
★★★★★  1911
★★★★  glock 22
★★★★  glock 30
★★★  22
★★★  xd 45
★★★  21sf
★★  glock 21sf
★★  41
★★  sig p220
★  glock 17
★  xdm 45
★  17
★  hk45
★  glock 19
★  glock 37
★  20
★  springfield xd
★  37
★  fnx 45
★  glock 20
  springfield xd 45
  sig sauer p220
  m&p 45
  hk usp 45
  glock 21c
  31
  sig p227
  21c
  sig 220
  ruger sr45
  glock 41
  springfield xdm 45

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glock 21
1911
glock 22