The best replacement for focusrite is presonus.

The best alternatives to focusrite are rated as following:
★★★★★  presonus
★★★★  motu
★★  apogee
★★  rme
★★  universal audio
★  mbox
★  tascam
★  motu preamps
★  m-audio
★  avid
★  komplete audio 6
★  m audio
★  mbox 3
★  apogee duet
★  avalon
★  mackie
★  steinberg
  presonus preamps
  vintech
  native instruments
  presonus audio interface
  tc electronics

Your alternative for focusrite is not listed? Suggest!
Speaking about focusrite, one probably shouldn't forget about pro tools.

Other search terms related to focusrite and their ratings are:
★★★★★ pro tools
★ pod farm
★ studio one
You have in mind a companion for focusrite and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of focusrite in all years. Click on graph for more.
focusrite
presonus
motu