The best replacement for flexible sigmoidoscopy is colonoscopy.

The best alternatives to flexible sigmoidoscopy are rated as following:
★★★★★  colonoscopy
★  rigid sigmoidoscopy
  sigmoidoscopy

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Google Trends

Scale is based on the average worldwide traffic of flexible sigmoidoscopy in all years. Click on graph for more.
flexible sigmoidoscopy
colonoscopy
rigid sigmoidoscopy